Obesity: A Complex Brain Disorder
- Dopamine Dysregulation: Alterations in dopamine signalling, which regulates reward and pleasure, can lead to overeating and food addiction.
- Leptin Resistance: Leptin, a hormone produced by fat cells, plays a crucial role in regulating energy balance. Leptin resistance can lead to increased food intake and weight gain.
- Insulin Resistance: Insulin resistance, a precursor to type 2 diabetes, can contribute to obesity by disrupting normal glucose metabolism and promoting fat storage.
- Gut-Brain Axis Dysregulation: The gut microbiome produces hormones and neurotransmitters that influence appetite, satiety, and metabolism. An imbalance of the gut microbiome, or dysbiosis, has been linked to obesity.
Mental Health Conditions That Contribute to Obesity
- Depression: Depression can lead to changes in appetite, either causing overeating or loss of appetite. Many people with depression turn to food for comfort, engaging in emotional eating. Research shows that individuals with depression were more likely to experience weight gain and obesity.
- Anxiety: Anxiety disorders often lead to emotional eating or stress eating. People with anxiety may seek solace in food as a way to cope with stress, leading to an increase in body weight. Scientific studies done in Singapore have found that anxiety was a major factor contributing to higher BMI (body mass index) among individuals.
- Bipolar Disorder: Bipolar disorder, particularly during manic episodes, can lead to impulsive eating habits and weight gain. People may also experience irregular sleep patterns, which can disrupt hunger-related hormones, promoting overeating.
- Eating Disorders: Some eating disorders like binge eating disorder result in excessive food consumption. In Singapore, research has shown that individuals with binge eating disorder are at a significantly higher risk of becoming obese.
- Insomnia: People with insomnia may experience changes in hunger hormones like ghrelin and leptin, which regulate appetite. These disruptions can lead to increased cravings and overeating, which can result in weight gain. Research indicates that people with chronic insomnia are more likely to develop obesity.
- Attention Deficit Hyperactivity Disorder (ADHD): ADHD is linked to impulsivity and difficulties in making thoughtful decisions. People with ADHD may struggle to make healthy food choices and are more prone to snacking impulsively, which can contribute to obesity.

The Mental Health Impact of Obesity
- Depression and Anxiety: Obesity significantly increases the risk of depression and anxiety disorders. Studies have shown that people with obesity are more likely to experience depressive symptoms, while the stress of managing obesity can also exacerbate anxiety.
- Body Image Issues: For some people with obesity, a negative body image and low self-esteem may be constant challenges. Society’s focus on thinness and the stigma surrounding obesity can lead to feelings of inadequacy and inferiority.
- Social Isolation: People struggling with obesity may withdraw socially due to shame or embarrassment, leading to feelings of loneliness and despair.
- Reduced Quality of Life: Obesity can limit an individual’s physical agility, mobility and lead to chronic health issues, which can in turn affect their mental well-being.
Scientific Data from Singapore: The Obesity-Mental Health Link

Managing Obesity for Better Mental Health
- Cognitive Behavioural Therapy (CBT): CBT can help individuals address emotional eating and improve their relationship with food. By tackling the underlying psychological triggers, CBT can help prevent overeating and promote healthier eating patterns.
- Physical Activity: Exercise is crucial for both physical and mental health. It helps reduce stress, improve mood and concentration, and manage weight.
- Healthy Eating Habits: Developing a diet plan and adhering to a balanced diet help individuals make healthy food choices that support both weight loss and mental health.
- Medication: For some individuals, medications to regulate appetite can help to facilitate weight loss. The medication Liraglutide works by mimicking a hormone called GLP-1 that naturally occurs in the body. It has been proven to be safe and effective in the treatment of obesity, especially when combined with lifestyle changes such as healthier eating and increased physical activity.
Benefits of Liraglutide
- Helps regulate appetite by slowing gastric emptying.
- Increase satiety and reduce hunger, helping to control food intake and prevent overeating.
- Improves insulin sensitivity, a key factor regulating weight.
The Importance of Seeking Help
If you or a loved one is struggling with obesity or mental health issues, it’s important to seek professional help. Addressing both the mental and physical aspects of obesity requires a holistic approach, and treatment is available.
At Private Space Medical, we provide personalized weight management treatment plans that incorporate psychological support and medical intervention to help individuals achieve lasting results. Our team of clinicians will carefully assess your needs and preferences, and tailor solutions to help you reclaim your health and well-being.
Take the first step towards better mental and physical health today. Contact us to schedule a consultation and embark on your weight management journey. Together, we can support you in achieving your weight management goals and improve both your body and mind.